Pull on heavy work gloves, long sleeves, pants and heavy shoes or boots before approaching bull thistle. This will protect you from the sharp, needle-like spines.
Step on the base of the bull thistle and lean the plant away from you with your foot to better avoid contact with the weed's spines.
Move your foot, reach down and pull the bull thistle out of the ground with a hard jerking motion to dislodge the root. The entire plant should pull easily out of the ground.
Chop up any remaining root in the ground with a hoe to prevent the bull thistle from re-emerging.
Till the soil in the area where bull thistle has been removed. Hoe or spade up smaller areas to prepare the soil for new plantings.
Sow seeds or place established plants in the tilled soil. Use native plants that can root easily and quickly in the soil for best results.
Cover root balls with soil and pat down firmly. Cover seeds gently with a fine layer of dirt, or use a rake to smooth them into the prepared soil.
Water the area thoroughly. Continue to water until seedlings emerge, or plantings become established.