Set the lettuce transplants outdoors in a protected area during the daytime, beginning five to seven days before transplanting. Bring the plants in at night or when frost in the forecast. A short period of outdoor acclimation helps avoid transplant shock.
Prepare the garden bed for transplanting in mid-spring when the soil thaws and begins to dry out. Break up the top 6 inches of soil with a hoe and work in your preferred fertilizer at the rate recommended on the label.
Lift the lettuce seedlings from the nursery pots, taking care to avoid damage to the stems and roots. Leave the soil ball around the roots intact.
Plant the seedlings in the garden bed at the same depth they were growing at previously. Space head lettuce 12 inches apart in the row, leaving a row spacing of 12 to 18 inches. Space leaf lettuce 4 to 6 inches apart.
Water the garden bed thoroughly after transplanting so the top 6 inches of soil becomes moist.