Plant the lettuce seeds or seedlings in the garden, following the spacing recommendations on the plant label or seed packet for the specific lettuce variety. Generally, space leaf lettuce 4 inches apart, butterhead 6 inches apart and head lettuce 12 inches apart.
Weed between the plants until the lettuce is approximately 6 inches tall. Pull weeds from between the seedlings by hand. Break up the top inch of soil between the rows with a hoe so that weeds can't root.
Spread a 2-inch layer of organic mulch, such as straw, over the entire lettuce bed once the seedlings are approximately 6 inches tall. Laying the mulch earlier can suppress and prevent the lettuce plants from growing.
Pull the mulch back from the base of each lettuce plant so there is a 1-inch space between the plant and mulch layer. Covering the base of the plant in mulch can cause rot problems.