Determine where you need to prune. Generally, you would prune any dead branches or prune to control growth.
Cut the branches at a 45-degree angle. If you're trimming a rose bush or other flowering shrub, cut 1/4 inch above the uppermost outward-facing bud.
Seal the cut with orange shellac to prevent insects or infection from attacking the plant. You can use a spray can of orange shellac, but those are not always readily available at home-improvement stores. Also, if your spraying technique is not correct, peeling can occur where the plant was cut. For that reason, it is generally preferred that you use a can of orange shellac and apply the substance with a paint brush.