Use products containing glyphosate to effectively destroy rosebushes up to 15 feet tall. The non-selective, general use herbicide is sold under different trade names and is effective for the control of all perennial and annual plants.
Spray herbicide evenly on all foliage. This process is referred to as foliar treatment. The best time to use glyphosate is during the active growth stage of plant between late spring and late summer as the chemical is then translocated at a faster rate throughout the plant including the roots.
Cover plant from all sides but do not drench the plant to the point of runoff. Avoid using glyphosate on hot days or on rose bushes that are drought stressed. Do not use when there is chance of rain within six hours of application.
Repeat application after about a week. Cut down the dead plant to the stump. Get rid of the stump by grinding or digging it out. If you cannot manually dig out the stump, you can tie a chain around it and pull it out by attaching to a truck or tractor.