Use herbicides with active ingredient glyphosate for effectively removing a Virginia creeper. Select the undiluted, water-soluble formulas because this type is more effective than the esters.
Locate the main trunk of the Virginia creeper. Cut the plant about a foot above ground level using an axe. Make the cut trunk surface as level and smooth as you can.
Pull down the creeper vines and discard. This process might take time because the plant might be tangled in surrounding vegetation.
Spray the top of the stump with the herbicide. Make sure you target only the stump. Use the herbicide on fresh plant tissues immediately after making the cut. If you were not able to spray right away, recut the stump to expose fresh wood prior to application of the chemical.
Avoid the use of glyphosate on very hot days or on plants that are severely drought stressed. Repeat application after seven to 10 days.
Dig out and remove the dead stump with a hoe. If stump removal is not possible with digging, you may grind the stump to a depth of about a foot below soil line.