Choose any herbicide with the active ingredient glyphosate for killing an unwanted tree, suggests the Washington State University Extension. Select an undiluted, water-soluble formula over an ester or oil-soluble formula for better efficacy.
Use a sharp ax to cut down the tree to a 2- to 3-foot stump. Make the stump surface smooth and level to keep the herbicide from dripping off. The best time to use glyphosate is in August and September.
Spray the entire surface of the stump, if the diameter is 3 inches or less. If the stump diameter is over 3 inches, spray the chemical only on the 2 to 3 inches right next to the bark, because the inner heartwood on larger trees is already dead.
Repeat application after seven to 10 days. Avoid using glyphosate on very hot days or on trees suffering from severe drought stress. The cambial tissue will move the chemical into the tree roots and gradually kill it entirely.
Use a stump grinder to grind the stump to a depth of about a foot below the ground. Grinding is the recommended method of stump removal in urban settings, cites the University of Minnesota Extension.