Select one male wild muscadine for every two female wild muscadine plants for your garden.
Plant the wild muscadine vines in a row in full sun with two female vines followed by one male vine. Dig a hole for the wild muscadine vines as deep as the plant's root ball and twice as wide. Place each plant into the hole and fill the hole with soil.
Water the wild muscadine vines two to three times a week for 5 to 10 minutes if there's no natural rainfall.
Allow the wind and insects to pollinate the wild muscadine when they are in flower. If you want to aid the pollination, break off a few male flowers from the wild muscadine and rub their pollen in the flowers on the female wild muscadine plants.