Select a herbicide with the active ingredient glyphosate for killing unwanted plants, including shrubs and trees in the garden, as suggested by the Washington State University Extension. You can effectively use glyphosate to kill wild rose as the chemical is effective on nearly all woody plants. Choose undiluted, water soluble formulas as these are more effective as compared with esters.
Spray the herbicide evenly on the foliage making sure you cover the bush from all sides. This is referred to as foliar treatment and is effective on shrubs up to the height of 15 feet.
Avoid drenching the foliage to the point of runoff. Do not use the herbicide on very hot days or on plants that are severely drought stressed. The best time to use glyphosate is during August or September.
Repeat treatment after seven to 10 days. Cut and remove the plant when it is dead. Dig out stumps with hoe or shovel. If stump is too large to dig out, grind it to a depth of about a foot below soil line using a stump grinder.