Take the cuttings from a large, mature night-blooming cactus in spring to mid-summer, when the cactus is in a growth phase. Take the cuttings in early morning for healthy, juicy plant matter.
Find sections of the cactus with new growth and no flower buds for best rooting. Cut several 2- to 4-inch-long sections, with 45-degree-angle cuts.
Prepare 6-inch pots for rotting. Mix sand and organic compost in equal parts, or use sand-based potting soil, and fill the pots to within 1 inch of the top. Moisten the top 4 inches of soil.
Stick the bottom 1 inch of each cutting into the soil, with several cuttings in each pot. Put the pots in sites with bright indirect light and water them with 1 inch of water every week. Too much bright light may burn the cuttings, while lack of light leads to yellowing and dying. Expect rooting in three to six weeks.