Don the proper attire before trimming back a Saguaro cactus, including long sleeves long pants and thick work gloves.
Examine the outer trunks to identify any that are leaning toward the ground. These trunks eventually will split off and fall because there should be only one central trunk. Trace the leaning trunks back to where they emerge from the ground and cut through them with a pruning saw.
Prune off branches in the upper portion of the tree that are touching each other. Cut off weakest or thinnest branches near the base of the central trunk.
Wrap an old carpet remnant around the pruned off pieces so you can pick them up. Discard them in a compost pile or in the garbage.
Sprinkle powdered sulphur over the surface of all pruned areas to help them callus over and prevent infection and disease.