Grow the Echeveria derenbergii in full sun. If you live in an area with hot summer sun, provide afternoon shade for the E. derenbergii.
Plant the succulent in a cactus mix or other fast-draining soil. You can make your own mix by combining 2 parts of sand and 2 parts of pumice with 1 part each of redwood compost and peat moss.
Provide the E. derenbergii with water when the soil feels dry to the touch in spring and summer. Withhold water in winter. Although this plant resembles a cactus, it grows in high elevations in nature and requires more water than a desert cactus.
Fertilize the E. derenbergii in the spring with a cactus and succulent fertilizer, diluted to half the strength recommended on the package. Too much fertilizer will harm this echeveria.