Purchase a type of blueberry bush that's suitable for growing in your region from a reputable garden center. Mississippi State University recommends rabbiteye cultivars of Climax, Brightwell or Baldwin or the southern highbush cultivars of Biloxi, Gulf Coast and O'Neal.
Dig a hole in a suitable location on your property. The spot should be clear of other plants, receive at least six hours of full sun, and have soil with a pH level between 4.5 and 5.2. Make sure the hole is slightly deeper than the roots of the plant.
Place the bush in the hole, and cover the base with either peat or mulch to help with soil drainage.
Water the blueberry bush with approximately 2 inches of water each week. Monitor the rain in your area, as watering may not be necessary.
Fertilize the blueberry bush each spring by applying 4 oz. of ammonium sulfate or fishmeal.
Prune the base of the plant only after it's been in the ground for three years.