Obtain a product containing hexazinone as a soil-applied chemical for the control of any size mesquite tree or shrub. You may treat the plants at any time of the year.
Dilute the chemical by mixing with equal amounts of water. Mix enough herbicide to cover three feet of ground space around the plant or tree canopy. You may also use the herbicide undiluted.
Apply evenly to soil using a drench gun or any other form of applicator. Water well after application to allow the chemical to move down into the roots. It takes at least two years for the plant to die entirely after application. The plant defoliates and regrows a couple of times before dying.