Hand weed plants such as creeping Charlie by slipping your fingers under the underground stem and removing all of the stem and roots. Repeat as more leaves appear. This will be more difficult in compacted soil. Repeat this up to 10 times. Place the weeds in a black plastic bag and leave it in the sun for several weeks to kill the weeds before disposing of them.
Spray an organic herbicide, such as pelargonic acid or herbicidal vinegar mixes, on the creeping plant. Cover nearby desired plants with a plastic bag to protect them before spraying with a weedkiller. Be prepared to repeat treatment on tenacious plants.
Apply a traditional weedkiller that contains glyphosate. Shield all desired plants, including grass, with plastic bags before spraying. Glyphosate will kill all plants.
Add boron to a lawn or garden to get rid of creeping Charlie. Dissolve 20 tsp. of borax, the most comonly available form of boron, per 1 gallon water. Borax is sodium borate, a salt of boron, and is commonly found in the detergent aisle. Disperse the solution across 100 square feet. Apply only once. Creeping Charlie is very susceptible to an increase in boron, but too much applied repeatedly will harm lawns and other plants.
Employ a broadleaf herbicide to kill the dicot creeping plants in the lawn. Do not spray this on any garden areas, as it will kill all dicots. Do not spray broadleaf herbicides near shrubs or trees. This will not kill any creeping grasses, as they are monocots.
Paint herbicides onto creeping plants that are too close to desired plants to spray. Soak a towel, sponge or brush with the herbicide. Squeeze out any excess fluid over a bucket. Wipe the damp towel over the leaves of the plant. Do not drip the toxic liquid on desired plants.