The Texas Cooperative Extension recommends the use of picloram for the control of cacti. The chemical is a systemic herbicide that's effective on a variety of broad-leaved weeds except mustard. Picloram is also widely used for woody plant control. Another weed killer, 2,4-D (known by trade names such as Weedtrine-II, Aqua-Kleen and Barrage) is cited as an excellent control strategy for cacti by the New Mexico State University Extension. A systemic herbicide, 2, 4-D controls a number of broad-leaved weeds as well as aquatic weeds.
To use picloram herbicide, mix the chemical with water to form a 1 percent solution. For example, the ratio is 4 oz. of picloram in 3 gallons of water, 18 oz. of chemical in 14 gallons of water and 1 qt. of chemical in 25 gallons of water. Also use a surfactant such as a dishwashing liquid as this helps the chemical adhere to the waxy surface of cacti. If the tank size is 3 gallons, use 1 oz. of the surfactant. In a 14-gallon tank, use 5 oz. of surfactant and in a 25-gallon tank use 8 to 16 oz. of the surfactant. Mix in a blue marking dye at the rate of ¼ to ½ percent in a 3-gallon tank as this helps in identifying the areas that have been treated.
For effective cacti control using 2,4-D, make a solution by mixing one part of the chemical to 20 parts water and three parts diesel oil. This results in 95 to 100 percent control, as cited by the New Mexico State University Extension. A gallon of this mixture is effective on 14 to 20 cacti such as cholla that have a mature height of up to 8 feet.
Start spraying the cacti with herbicide solutions at the start of the active growth period and during daytime temperatures of about 60 degrees. Cacti that are in bloom respond best to treatment. Make sure all the pads are thoroughly coated on both sides but don't wet to them the point of runoff. Avoid treatment in windy areas to minimize the risk of drift to desirable plants. Don't spray wet plants.