Wait for dusk or just before dawn, to ensure that the bees are not highly active. Spray the nest during these times to target as many bees as possible inside the nest.
Stand 15 to 20 feet from the nest, facing the opening. Hold the can of Raid Wasp, Hornet and Bee Killer upright.
Press the nozzle to spray a steady stream of Raid at the nest. Saturate the nest thoroughly, aiming some spray directly at the opening of the nest as well.
Wait 24 hours for the pesticide to work thoroughly, before you remove the nest from the area. If you still see activity after 24 hours, do not remove the nest yet. Repeat the treatment and wait an additional 24 hours.