Don the wasp suit. Professional wasp suits are available for purchase. If one is not available, it is not recommended that you attempt to remove a hornet nest.
Spray insecticide into the opening of the nest. Hornet nests only have one opening that is usually located somewhere near the bottom half. Be careful not to touch or break apart any portion of the nest during this process.
Wait 24 hours after spraying the insecticide to return to the nest. If you still observe hornets in the area, spray the insecticide in the nest again. Repeat this process until you no longer observe hornet activity.
Remove the nest by hand. Even if you haven't seen hornets in a while, be safe and wear your wasp suit. It is also recommended that you keep the nest intact during this final removal.