Remove dead or diseased branches on the outside of the overgrown azalea with a pair of sharp hand pruners. Cut dead branches where the dead branch meets another branch of the azalea.
Use the loppers to cut off dead or diseased branches that extend to the stem of the overgrown azalea bush. Trim azalea branches 6 inches into the healthy part of the branch.
Clean your hand shears and pruning loppers by sterilizing them with alcohol or 1 1/2 cups of bleach with 2 gallons of water. Sterilizing your pruning tools will prevent the spread of disease to other bushes and trees.
Cut back severely overgrown azaleas to 6 to 12 inches in height from the ground. Leave the healthiest branches to encourage new growth when your azalea bush blooms again.