Plant variegated holly in a full-to-part-sun location. Variegated plants often require less sun than their solid-green counterparts to retain variegated color. Too much sun may cause reversion in some variegated plants.
Water regularly until the holly is established in the landscape. For the first year after planting, growing holly needs roughly an inch of water per week. Provide more water as needed during hot, dry summer days.
Initiate berry production by planting both a male and a female holly. Female plants can have a heavy berry set but most need a male pollinator within 30 to 40 feet to produce.
Prune variegated hollies annually. Prune during dormancy in winter. Many variegated hollies have sparse foliage and limited branching. Prune the top of the main branch and ends of horizontal branches to encourage dense foliage to develop.
Limit fertilization of variegated holly. Nitrogen can build up around roots and damage the plant.