Scrape away excess polish that has pooled up on the leather with a spatula.
Dab the nail polish with a dry paper towel until the paper towel comes away clean.
Mix dish detergent and warm water in a bowl until suds form. Saturate a sponge in the soapy water.
Dab at the nail polish stain with the sudsy sponge. Rinse the sponge in the soapy water as needed.
Squirt leather cleaner onto a clean sponge if the nail polish stain remains. Rub the ends of the sponge together until a lather forms.
Rub the nail polish stain gently with the sponge. Reapply leather cleaner as needed. Continue gently scrubbing the stain with the sponge until it disappears.