Scrape off as much of the nail polish off as possible if it is still wet. To do not wipe or rub, which can worsen the stain. Use a disposable object, if desired, such as a plastic spoon or a Popsicle or wooden craft stick for this step.
Moisten a cotton ball with nail polish remover or acetone. Check the label; if your slippers are made from acetate, triacetate or modacrylic fabrics, do not use nail polish remover or acetone, recommends the University of Illinois. You can try rubbing alcohol instead. For nonwashable fabrics, moisten a cotton ball with a dry cleaning solvent or take the slippers to the dry cleaners.
Blot the cotton ball on the back side of the stain if it seeped through the slipper. Otherwise, blot the moistened cotton ball on the front of the nail polish stain until all the nail polish is removed. You may need several cotton balls for this job, depending on the size of the stain.
Moisten the area with hydrogen peroxide if the stain persists, but since it may alter the slipper’s color, use this as a last resort. If some of the stain remains after one hour, repeat once more.
Spot clean the area with a drop or two of laundry detergent and warm water after the stain is removed. Rinse with a moist rag. If the slipper is washable, wash it the washer.