Rotate the comforter every morning. Part of what causes the cotton to become balled up is your movement at night, so rearrange which parts bear the brunt of your motions.
Shake the comforter out by grasping one edge firmly in your hands and flapping the comforter up and down. This helps redistribute the cotton in the comforter while also airing it out.
Hang your cotton comforter over a clothesline and beat it soundly with a mattress beater or a carpet beater. This shakes out any dust as well as redistributes the cotton.
Place the comforter in the dryer and dry it on low heat. Place two or three clean tennis balls in the dryer with the comforter to pound it into shape.