Check the label on the back of the place mat for any care instructions. Follow these instructions to avoid damaging the place mats.
Treat any stains on the place mats with a stain remover before you wash the mats. Dab the stain remover onto the stains, and rub gently to loosen them.
Wash the place mats with your regular detergent in a washing machine. Set the water temperature to cold to keep the colors from fading or bleeding.
Dry the place mats in a clothes dryer on a low heat setting to keep them from shrinking. Remove them from the dryer immediately after the cycle is finished, and flatten them with your hands to prevent wrinkles.
Remove stubborn wrinkles by ironing the place mats. Set the iron to a medium-hot temperature, or around 250 degrees Fahrenheit.