Mix 3 cups of warm water and 1 cup of mild laundry detergent in a bucket. Wear latex gloves to keep your hands dry.
Use a funnel to guide the mixture into a 16 oz. spray bottle. Shake the mixture gently from side to side.
Take any linens off your Tempur-Pedic foam mattress and set them aside.
Spray the soap mixture on the foam material. Do not let the mixture soak into the material.
Blot the foam immediately with a sponge to remove any dust, dirt and stains. For heavy stains, let the soap mixture sit on the spot for 3 minutes, then blot the stain to remove it. Note, blotting doesn't push the stain farther into the foam.
Wet a soft cloth or rag with warm water from a sink. Wring out excess water. Wipe the foam mattress thoroughly with the damp cloth or rag to remove any soap residue.
Press a large towel into your Tempur-Pedic foam mattress to dry the material. Let the mattress fully dry before redressing your bed.
If your foam mattress has an odor, do not redress the bed yet. Proceed to the “Removing Odors” section.
Sprinkle baking soda evenly on your foam mattress.
Let the baking soda sit for 5 minutes.
Use your vacuum cleaner's crevice or brush attachment to remove the baking soda from your mattress.