Remove any cushions from the leather sectional. Vacuum the sectional with a soft brush attachment, or run a clean, dry microfiber cloth over the surface to remove any dust or dirt.
Fill a bucket with 1 gallon of warm water and 2 tablespoons of mild liquid soap. Dip a cloth into the bucket and wring out the excess water.
Wipe the sectional thoroughly with the cloth. Work on one section at a time, cleaning the cushions, sides and back of the sectional as well.
Empty the bucket and refill it with clean, cool water. Rinse away any soap residue with a clean, damp cloth.
Dry the Natuzzi leather sectional and cushions with a soft, absorbent towel.