Wipe loose dust and grime off of your desk with a clean, dry wash cloth. Wiping your desk down on a regular basis can help you remove a significant amount of dirt without the use of any additional chemicals.
Spray or pour wood polish onto a clean wash cloth and wipe down the wooden parts of your desk to remove dirt from the wood and bring out its natural shine.
Clean the leatherette portion of your desk by wiping it down with a damp wash cloth and mild liquid soap. Leatherette is not real leather; it is a type of plastic, and you can use virtually any plastic-safe cleaning product on it without having to worry about damaging it.