Position the safe in its final location.
Open the safe door and locate the bolt holes inside. Use a marker to color the ground visible through the bolt holes.
Move the safe away from location.
Drill a 3- to 4-inch deep hole into the floor underneath each colored circle, using a drill bit sized to match the diameter of the anchor bolts you'll be using. Use a standard bit for wooden floors and a masonry bit in concrete floors. Cut away any carpeting before drilling the holes.
Vacuum the dust and debris out of the holes and the nearby floor.
Slide the safe back into its final location. Line up the bolt holes with the holes you drilled in the floor.
Shove the anchor bolts through the bolt holes in the safe and into the drilled holes underneath. Tap the top of the bolt gently with a hammer to help work stubborn bolts into their holes.
Tighten the nut on the top of the bolt with a wrench or pair of pliers. Continue until the bolt's sleeve expands enough to securely anchor the safe to the floor.