Position the safe on the floor in the exact location where you wish to bolt it. Set a level on the safe and adjust it as necessary. Open the safe and lift the access panel on the safe's bottom to reveal the bolt holes. Mark the bolt holes' location on the floor and move the safe aside.
Drill holes through each bolt hole marking. If the floor is concrete, use a hammer drill and masonry bit. If the floor is wood, use a drill and drill bit. The size of bit you use, for either concrete or wood floors, depends on the size of the bolts provided by the manufacturer.
Lift the safe back onto its permanent location. Line up the holes in the floor with the safe's bolt holes. Slide a thick washer onto each of the bolts. If the floor is concrete, the bolts come with a sleeve. Hand-tighten the bolts into the sleeves and hammer one sleeve into each hole.
Tighten the bolts in place with a drill and bolt driving bit. The size of driving bit you use depends on the size of the bolt's head. Close the access panel.