Draw a line on a piece of scrap wood running parallel to the base of the jigsaw.
Unplug your Ryobi jigsaw and turn on the laser sight power switch on the side of the saw.
Use a screwdriver to turn the laser adjustment screw, located next to the laser power switch, 1/2-turn to the right if the laser point falls on the left-hand side of the drawn line. Turn the laser adjustment screw 1/2-turn to the the left if it falls to the right. Do this until the laser point is directly in the center of the line.
Plug in the saw and test the sights by cutting the piece of wood. If it is still slightly off, unplug your Ryobi and readjust the laser sights.