Place the acrylic panel on the table of the drill press. Center it under the drill and clamp it down with the hold downs on the table of the press. If your drill press doesn’t have hold downs, you can clamp it down with two C-clamps.
Insert the hole saw bit that is the size of the recess in the router table into the chuck of the drill press. Drill down through the acrylic panel in a steady motion, applying just enough pressure to allow the bit to saw the circle out.
Remove the acrylic panel from the table of the drill press. Clamp the circle that you cut out down to the table of the drill press with the hold downs or C-clamps. Take the hole saw bit out from the chuck and insert the Forstner bit.
Drill a hole through the center of the circle with the Forstner bit. Remove the circle from the drill press and place it on a work surface.
Sand the edges of the circle lightly with a fine-grit sanding pad to remove any rough edges from the surface.