Cut into the seal between the glass and frame with a box cutter. Cut down the length of the seal.
Use your fingers to peel off the sealant from the frame.
Scrape the residual sealant off the frame with a putty knife.
Put on gloves and safety goggles. Dip a rag into acetone. Thoroughly wipe the seal area of the frame. Clean the area again with a rag dipped in water. Dry the area with a clean rag.
Mask the glass and borders of the frame with masking tape.
Apply new ammonia-based or polyurethane sealer to the gap between the frame and the glass. These sealers usually come in a caulking gun or other dispenser. To apply, discharge a single line of sealer along the gap between the frame and glass. Allow the sealer to dry for the length of time recommended by the manufacturer.