Stand the plexiglass sheet against a wall, or set it on a table, with it standing on an edge, so that you have access to the entire sheet of plexiglass. Standing the plexiglass on an edge will prevent scratching while it is on the table.
Place the safety goggles over your eyes to protect against any pieces of debris, dust or particles that might fly off the plexiglass.
Press down on the trigger to release the stream of compressed air from your can. Spray in a left to right motion from the top of the plexiglass to the bottom to remove any dust. Avoid spraying for more than 30 seconds at a time, as the can will get very cold.
Wipe down the plexiglass sheet with a soft, dry lint-free cloth. Move from the top of the plexiglass to the bottom to ensure that all of the debris is removed.