Wet the area with the lichens. This is unnecessary if the copper sulfate is being applied as a solution with a sprayer or wet applicator. Additionally, wetting is not necessary if the roof is wet immediately after a rain event or from dew.
Sprinkle the copper sulfate on the problem area. Follow manufacturer instructions and take all safety precautions as instructed while using the powder. Or, apply the copper sulfate with the wet applicator. Leave the copper sulfate on the roof for an extended period. The copper sulfate may require several weeks to effectively kill all the lichens.
Scrape off the lichens after they are dead and can flake off with minimal effort. The entire lichen growth may be removed easily or will fall off on its own within a few months.