Clean the area where you will be applying caulk. Dust or debris will inhibit the caulk's adhesion. Before applying silicone, wipe the area with denatured alcohol.
Bring caulk to room temperature. If it is too cold, it will not flow well. Cut a small hole in the end of the tube with a utility knife held at a 45 degree angle. Cut off only the tip, making a small oval hole that makes a bead of caulk about 1/8 of an inch wide. If the hole is too small, you can always cut it bigger later. If the hole is too big, the caulk will be messy and difficult to control.
Place the tube in the caulking gun, but do not advance the plunger until you are ready to apply. Begin caulking by placing the bevel of the cut tip in the joint at a 45 degree angle so the cut faces the joint. Advance the plunger with consistent pressure as you draw the caulk down the joint, forming a small bead. With a little practice, you will be able to regulate the pressure and speed to form a uniform bead.
Smooth the caulk by drawing a wet finger or a caulk edging tool, with even pressure, down the joint. Caulk smoother may be sprayed onto the caulk before smoothing. It lubricates the caulk so it doesn't stick to your finger, making it easier to get professional-looking results and easier clean-up. Clean your edging tool or finger frequently with a wet rag. Dry or drying caulk residue will gouge and stick to your bead, causing irregularities in the finish.