Remove the seat from the toilet if it is attached. Remove the hinges from the seat and set the hardware aside. Take the seat to an area where you can sand and paint conveniently.
Sand the toilet seat using 150- to 180-grit sandpaper. Smooth any rough edges. Wipe away any wood dust.
Apply paint primer with a sponge. Smoothly apply the primer to the entire toilet seat and allow to dry, following manufacturer's recommendations for drying time.
Spray the seat with enamel paint. Coat the entire seat and allow to dry. Apply a second coat.
Spray or sponge on a final coat of polymer-based clear coat. This seals and protects the paint.