Strip the original paint off of the garage door using a solvent, such as mineral spirits or paint thinner. Spread the solvent on the door with a paintbrush or rag, then scrape the paint away with a paint scraper.
Wash the garage door with a solution made of trisodium phosphate and hot water. Use about 1/4 cup of TSP for every gallon of hot water. Scrub the garage door with this solution and a scrub brush.
Rinse the door with fresh water and a damp cloth. Allow the garage door to dry completely.
Apply exterior latex primer to the garage door with a paintbrush or a paint roller. Spread the primer thinly and evenly. Allow the primer to dry.
Paint the garage door with exterior latex paint. Use the same tools and process you used with the primer. If desired, paint the garage door with a second coat of paint once the first coat dries.