Use a screwdriver to remove the screws on the drain cover plate.
Clean the drain hole underneath the cover plate, using a scrub pad and a mild cleanser, if necessary. Mold and mildew should be removed as well.
Stuff a handful of fiberglass insulation into the drain hole so that it is filled. Wear gloves while working with the insulation.
Mix up a small batch of two part epoxy resin according to the instructions and use a putty knife or small trowel to cover the fiberglass insulation-filled hole.
Allow the first application to dry and then apply other coats as needed to fill the hole.
Let the epoxy cure thoroughly.
Sand the epoxy with 80-grit sandpaper until it is flush with the tub.
Wipe away any sanding dust and reattach the cover plate with the screws.