The manufacturer, Masterchem® Industries, Inc., recommends that all windows and doors be opened while applying Kilz paint. Also suggested is that the painter wear protective gloves, safety glasses with side shields and other protective clothing to cover the main parts of the body. Respiratory protection is only recommended if the worker experiences dizziness, headaches or watery eyes. Anyone experiencing these symptoms is also suggested to increase the amount of fresh air or leave the area right away.
According to the MSDA data sheet, paint applicators should avoid any direct heat to Kilz paint for "closed containers may explode when exposed to extreme heat." Also to be avoided are any sparks or static electricity in the vicinity of the paint vapors for ignition could occur.
Also listed on the data sheet is the statement that the chemicals in Kilz paint are stable, that they are not carcinogenic nor will they breakdown into a hazardous by-product.