Open the cabinet door or drawer, and unscrew the wooden knobs from the inside, using a screwdriver or a power drill. Store the screws in a plastic storage bag for safekeeping.
Place cardboard or a small folded drop cloth on a tabletop or workbench. Place the wooden knobs on top of the cardboard.
Put on a pair of rubber work gloves and wipe each wooden knob with a degreaser product, using a clean rag. The degreaser removes stubborn dirt and accumulated cooking grease.
Sand each wooden knob, using sandpaper or a drywall sanding sponge. Sand firmly enough to gradually remove the protective finish and expose the pores in the wood grain underneath.
Wipe each knob with a slightly damp rag to remove sanding dust. Dust off the surface of the work table, using a paint brush.
Lightly dip the end of a 1-inch paint brush into a container of oil-based primer. Hold the side of the wooden knob with one hand and brush the primer onto the entire surface. Prime each knob and allow the primer to dry.
Open a can of acrylic semi-gloss paint and dunk the bristle ends of a clean 1-inch paint brush into the paint. Paint each wooden knob with a light coat of the acrylic paint. Allow the first coat to dry.
Paint a second coat of semi-gloss on each knob, using the 1-inch paint brush. Apply a third coat of paint if the knob color appears hazy. Allow the acrylic paint to dry before screwing the knobs back onto the cabinets or drawers.