Examine the ducts for any signs of leaks. Dents and holes provide areas where air escapes and these need to be repaired and sealed before adding the insulation. Tighten the connections between ducts if necessary as well to prevent temperature loss. Seal small leaks by applying aluminum foil tape to them.
Wash off the ducts with warm water and a sponge to remove dirt or dust. The ducts become more difficult to clean once the insulation is applied.
Wrap insulation wrap around the entire duct. Some wraps come with self-adhesive so they stick to the duct work. If your wrap doesn't, use zip ties every few feet to secure the insulation to the duct. Be sure to get insulation with the proper R-value for your location. The higher the R-value, the more resistant your duct will be to temperature loss.