Switch the control on the wall thermostat to either heating or cooling and adjust the thermostat so the HVAC unit turns on.
Position the stepladder below the ductwork where you can see a metal rod protruding from the side of the main duct, typically near a Y-junction where the ductwork splits in two directions.
Insert the tip of the screwdriver into the slot at the end of the metal rod, which controls the damper. Turning the rod clockwise until the slot is parallel to the ductwork opens the damper to the widest position.
Turn the rod counterclockwise until the slot on the end is perpendicular to close the duct completely.
Test airflow in the building for your personal comfort level and make further adjustments as necessary to the ductwork. Some experimentation may be necessary before you find the optimal settings for your home and preferences.