Inspect the air conditioning unit and all of the ducts in the attic. Reconnect and seal any disconnected ducts, and insulate the connections with foam sealant.
Use insulating foam sealant to seal where the ducts connect to the HVAC boot that goes into your home as well as around the boots in the drywall.
Remove the vents from the ceiling to inspect the metal box that delivers the air to each room. If there is a gap between the metal box and the ceiling, clean it and fill it with a high quality silicone caulk or piece of rubber weatherstripping. Replace the vents.