Brush any dirt or residue out of the joint using a stiff-bristle brush.
Open a tube of exterior-grade caulk using a sharp knife or scissors. Insert a nail into the head of the caulk to release the sealant. Use a caulk that is designed for the materials you are joining, such as vinyl siding and wood.
Insert the tube into a caulking gun and insert the nozzle into the back of the joint. Depress the plunger and line the crack with a continuous bead of caulk.
Wet a rag and wipe it over the caulk so it is flush to the wall and looks smooth.