Move the selector switch on the insulation tester to the voltage of the wires being tested.
Connect the "+" test lead to the hot wire. In residential electrical, this is typically the red or black wire.
Connect the "-" test lead to the neutral wire. In residential electrical, this is typically the white wire.
Press the "Test" button on the insulation tester. If your unit is a manual device, crank the hand crank at less than 180 revolutions per minute.
Look at the meter's needle for the indicate value of the insulation resistance in "MΩ".