Make sure the mode switch is in the "Heat" position if you're heater is producing heat. Check the set point temperature, and make sure it's higher than the room temperature displayed on the screen. Wait a few minutes if your unit doesn't turn on right away, because it may have a minimum-off time delay feature.
Move the mode switch to the "Cool" position if your air conditioning unit isn't cooling. Press the up or down arrow buttons to adjust the set point temperature. Make sure the temperature you select is lower than the one displayed on the screen or your air conditioner will not cool.
Turn on the fan if you don't feel a cool or hot breeze depending on the unit you're using. Locate the fan switch on the Aprilaire control panel and turn it on. You may also need to turn on the fan at your thermostat if you want continuous fan operation in all the zones.