Remove all knobs, handles and hardware from the piece with a screwdriver.
Wipe down the entire piece of furniture with a solvent-based cleaner on a cleaning cloth.
Sand all surfaces with 150-grit sandpaper. Wipe with a soft, damp cloth or tack cloth to remove the sanding dust.
Paint all surfaces with a bonding primer designed for plastic laminate, using a paint brush. Allow 45 minutes to one hour for alcohol-based shellac primers to dry or two to three days for an oil-based bonding primer.
Sand the dry primer lightly with 220-grit sandpaper. Clean away all sanding dust.
Paint the entire dresser, desk or cabinet with two to three thin coats of oil or latex paint. Allow the paint to dry completely before replacing the hardware.