Measure from the top of the back of the frame to the bottom of the hanger grid. Record the measurement.
Measure up your wall to the spot where you want the top edge of the picture frame to be located. Make a pencil mark on the wall at this point.
Measure down from the pencil mark the distance recorded in the first step. Make a pencil mark on the wall.
Place your picture-hanging hardware at the second mark and install into the wall according to the directions provided with the hardware. Be sure to follow instructions and use hardware rated for the weight of your picture frame.