Draw a rough bird's eye view of the room you are going to tile. Decide upon what type of tiles you are going to use and the design you want. Cut the mesh of the smaller tiles to size and dimensions needed according to your drawing.
Find the approximate center of the room by drawing two diagonal lines from opposing corners with a pencil and chalk line. The lines will cross the room in approximately the center. In a square room this process will find the exact center of the room, but most rooms are not perfectly square.
Apply tile adhesive in small sections of the floor at a time. Doing so will prevent the adhesive from drying before you place the tiles in case you change your mind about the design or need extra time laying the smaller sized tiles.
Spread the adhesive evenly across the small area you are working on with the notch side of the trowel. For glass tiles, use the flat side of the trowel to remove the lines in the adhesive that are left by the v-notches.
Lay the first larger tile in your design in the adhesive first. Lay the smaller tiles, with the mesh side down, around the larger tiles according to your drawn design.
Spread a hand towel over the tiles. Use the trowel to gently push the tiles into the adhesive until the tile corners are flush.
Finish one section of the floor extending from the center tiles to one corner before working on another section. Save the corner of the room with the exit door for last to guarantee you can leave once the tiles are placed. Allow 48 hours for the tiles to set.
Fill the spaces between the tiles with grout. Spread the grout across the floor and press it between the tiles by running the grout float across the tiles. Take care around the smaller tiles to press slowly to not pull them out of place.
Wipe the surface of the tiles with a damp sponge to remove the excess grout. Allow the tiles to set for three hours before walking on the floor.