Set the nightstands on a painter's tarp in a large, well-ventilated area. Remove any drawers and set them aside.
Sand the surface of the nightstands with a medium-grit sandpaper, moving with the grain of the wood. This creates a slight texture on the surface, which allows paint to stick better.
Paint the nightstands and drawer faces with one coat of latex paint using long, broad strokes with a large, flat paintbrush. When distressing furniture, use two different shades; the bottom color will show through the top coat once you complete the distressing process.
Let the bottom coat of paint dry. Apply another coat of paint -- in a different color, if desired -- and let the nightstands dry for at least 24 hours.
Rub the edges of the nightstand with a sheet of coarse sandpaper while wearing a face mask. Rub until you being to see the bottom layer of paint showing through. Do this for all corners and edges to complete the distressed look.